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United States. Annals of Epidemiology, 3: Most importantly, he explores the profound impact that the transducing of biological information into a digital format already has had on biological research and medicine, and the equally profound effect it is sure to have on our understanding of ourselves and all living creatures.

The Biogenesis of Cellular Organelles The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell.

This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated.

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Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers.

Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type or even subtype a selection of them are extremely important.

For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment.

The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.

Biology and Knowledge Revisited From Neurogenesis to Psychogenesis It focuses on classic issues between nature and nurture in cognitive and linguistic development and their neurological substrates. Specifically, it focuses on the experience-contingent, experience dependent nature of brain development and its evolution. It illustrates the benefit of the principles of geriatrics in the management of cancer in the older individual.

This volume provides a frame of reference for practicioners of any specialties involved in the management of older patients and for oncologists involved in the management of cancer of older individuals. It is a source for basic and clinical scientists exploring the interactions and emerging information of cancer and aging. Analysis of Genes and Genomes Presents the most current, clear, comprehensive, and balanced introduction to genetics and genomics at the college level.

Imagination And Its Pathologies From John Locke's Essay Concerning Human Understanding to the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders, madness has been viewed as a faulty mix of ideas by a deranged and violent imagination.

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This book shows that the relation of the imagination to pathological phenomena is as diverse and complex as the human condition itself. The imagination has the power not only to react to the world but to recreate it. And that power is double-edged: Recent advances in genetics and neuroscience have reinforced the empiricist approach in psychiatry, to the neglect of subjective aspects of the pathological experience. This book argues that the study of the imagination and pathology is long overdue, and that such an integration will be both theoretically and clinically fruitful.

Because imagination can be creatively integrative as well as pathological, the book emphasizes the holistic, therapeutic dimension of imagination as well as its destructive effects. The areas discussed include philosophical perspectives on pathological imagination; pathological imagination and the psychodynamic tradition; and specific cases of pathological imagination in schizophrenia, juvenile pathology, artistic creativity Vaslav Nijinsky , and religious expression St.

We can learn to be calm in the midst of the storm. Finding the Center Within offers a step-by-step program for breaking down the barriers that prevent us from actualizing our wise inner self. The Biens combine Eastern spiritual wisdom with the pragmatic wisdom of Western psychology, teaching us how to remove the walls that conceal who and what we really are and face our lives with greater honesty.