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Skip to Content Skip to navigation. Research output: Uncertainty exists regarding the optimal dosing regimen for vancomycin in different patient populations, leading to a plethora of subgroup-specific pharmacokinetic models and derived dosing regimens. We aimed to investigate whether a single model for vancomycin could be developed based on a broad dataset covering the extremes of patient characteristics. Furthermore, as a benchmark for current dosing recommendations, we evaluated and optimised the expected vancomycin exposure throughout life and for specific patient subgroups. A pooled population-pharmacokinetic model was built in NONMEM based on data from 14 different studies in different patient populations. The final model uses postmenstrual age, weight and serum creatinine as covariates.
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